A coupled analysis of sloshing in floating structures by integrating moving particle semi-implicit (MPS) method with a time domain multibody dynamic analysis software

Sloshing effects inside partially filled tanks on LNG carriers and FPSOs motions cannot be ignored. It is necessary to analyze the floating structures motion with the sloshing behavior simultaneously to obtain more accurate stability predictions because the phenomenon may affect the safety and the operability of the vessels in seaways and during loading and offloading process. In the present study, in order to model the coupled effects of platforms motion in waves and the liquid sloshing inside its tank, a hybrid timedomain simulation approach based on the integration of two simulators is proposed. The Numerical Offshore Tank (TPN) simulator, which is a time domain multibody dynamic analysis software, is used for the simulation of open domain hydrodynamic forces. It is able to perform calculations of coupled floating structures motion with the dynamic of mooring and connection lines and risers considering environmental condition such as wave, current and wind. In the other hand, due to the highly nonlinear aspect of the sloshing phenomenon, the Moving Particle Semi-implicit (MPS) method, which demands huge computing resources and it is more suitable to confined domain problems, is used to simulate the sloshing motion and to calculate the loads on the tank walls. The effects due to sloshing is then feed-backed to the TPN simulator as additional force and moment to solve the motion equation of the floating structure. The calculation can be distributed in a PCs cluster and each sloshing tank is solved in a different node. In this way, it allows the calculation of many tanks without increasing the computational time. Simulations were carried out with and without considering the coupled sloshing motions, and the results were compared to assess the effects of the liquid cargo sloshing on the motion of the floating structure

Fundamentos do processo criativo de estampas com DNA cultural brasileiro

O estudo parte do conceito que a estampa pode ser considerada um dos possíveis diferenciais de um projeto de Design de Moda.&nbsp

Computational Approaches Drive Developments in Immune-Oncology Therapies for PD-1/PD-L1 Immune Checkpoint Inhibitors

Funding Information: This research was funded by Fundação para a Ciência e Tecnologia (FCT) Portugal, grant number UIDB/50006/2020 (LAQV-REQUIMTE), UIDP/04378/2020 and UIDB/04378/2020 (UCIBIO) and LA/P/0140/2020 (i4HB), the European Commission GLYCOTwinning (GA 101079417), the EJPRD ProDGNE (EJPRD/0001/2020 EU 825575) and SI I&DT, DCMatters (AVISO Nº 17/SI/2019) REF 47212. F.P. gratefully acknowledges FCT for an Assistant Research Position (CEECIND/01649/2021). Publisher Copyright: © 2023 by the authors.Computational approaches in immune-oncology therapies focus on using data-driven methods to identify potential immune targets and develop novel drug candidates. In particular, the search for PD-1/PD-L1 immune checkpoint inhibitors (ICIs) has enlivened the field, leveraging the use of cheminformatics and bioinformatics tools to analyze large datasets of molecules, gene expression and protein–protein interactions. Up to now, there is still an unmet clinical need for improved ICIs and reliable predictive biomarkers. In this review, we highlight the computational methodologies applied to discovering and developing PD-1/PD-L1 ICIs for improved cancer immunotherapies with a greater focus in the last five years. The use of computer-aided drug design structure- and ligand-based virtual screening processes, molecular docking, homology modeling and molecular dynamics simulations methodologies essential for successful drug discovery campaigns focusing on antibodies, peptides or small-molecule ICIs are addressed. A list of recent databases and web tools used in the context of cancer and immunotherapy has been compilated and made available, namely regarding a general scope, cancer and immunology. In summary, computational approaches have become valuable tools for discovering and developing ICIs. Despite significant progress, there is still a need for improved ICIs and biomarkers, and recent databases and web tools have been compiled to aid in this pursuit.publishersversionpublishe

Implementation of an audit tool to make a diagnosis of patient safety in the external consultation service capitated by IPS Foscal Floridablanca headquarters

La Seguridad del Paciente es una prioridad de la atención en salud en nuestras instituciones, los incidentes y eventos adversos son la alarma que alerta sobre la existencia de una atención insegura. Los eventos adversos se presentan en cualquier actividad y son un indicador fundamental de su calidad”. 5 “ Colombia se impulsa una Política de Seguridad del Paciente, liderada por el Sistema Obligatorio de Garantía de Calidad de la Atención en Salud SOGC, cuyo objetivo es prevenir la ocurrencia de situaciones que afecten la seguridad del paciente, reducir y de ser posible eliminar la ocurrencia de eventos adversos para contar con instituciones seguras y competitivas internacionalmente”1 ; así, desde junio de 2008, el Ministerio de la Protección Social expidió los “Lineamientos para la implementación de la Política de Seguridad del Paciente”. Es reconocido ahora a través del Decreto 2309; actualmente el Decreto 1011 de 2006 y sus resoluciones 1043, 1446, 1445 de 2006, que la seguridad de la atención en salud juega un papel preponderante en la evaluación de la calidad y señala al índice de vigilancia de eventos adversos como el indicador básico.Universidad CES1. FORMULACION DEL PROBLEMA 8 1.1. PLANTEAMIENTO DEL PROBLEMA 8 1.2. JUSTIFICACION 9 2. MARCO TEORICO 11 2.1 PRESENTACIÓN DEL SERVICIO DE CONSULTA EXTERNA FOSCAL SEDE FLORIDABLANCA. 11 2.1.1 Reseña histórica. 11 2.1.2 Servicios que se prestan en la sede Floridablanca 11 2.1.3 Recurso humano 12 2.2 SEGURIDAD DEL PACIENTE 13 2.4 DEFINICIONES 16 2.4.2 Objetivos de la política de seguridad del paciente 17 2.5 NORMATIVIDAD 20 3. OBJETIVOS 22 3.1 GENERALES 22 3.2 ESPECÍFICOS 22 4. METODOLOGIA 23 4.1 DISEÑO Y TÉCNICA DE RECOLECCIÓN DE DATOS 23 4.2 POBLACIÓN Y MUESTRA 23 4.3 PROCEDIMIENTO 23 4.4 PLAN DE ANÁLISIS 24 5. CONSIDERACIONES ETICAS 25 4 6. CRONOGRAMA DE ACTIVIDADES 26 7. PRESUPUESTO 27 8. ANALISIS DE RESULTADOS 28 CONCLUSIONES 33 BIBLIOGRAFIA 35 ANEXOS 37EspecializaciónPatient Safety is a priority of health care in our institutions, incidents and adverse events are the alarm that alerts about the existence of unsafe care. Adverse events occur in any activity and are a fundamental indicator of its quality ”. 5 “Colombia is promoting a Patient Safety Policy, led by the Mandatory System for the Quality Assurance of Health Care SOGC, whose objective is to prevent the occurrence of situations that affect patient safety, reduce and, if possible, eliminate the occurrence of adverse events in order to have safe and competitive institutions internationally ”1; thus, since June 2008, the Ministry of Social Protection issued the “Guidelines for the implementation of the Patient Safety Policy”. It is now recognized through Decree 2309; Currently Decree 1011 of 2006 and its resolutions 1043, 1446, 1445 of 2006, that the safety of health care plays a preponderant role in the evaluation of quality and points to the adverse event surveillance index as the basic indicator.Modalidad Presencia

Microalgae-bacterial biomass outperforms PN-anammox biomass for oxygen saving in continuous-flow granular reactors facing extremely low-strength freshwater aquaculture streams

The dissolved oxygen (DO) concentration in water streams is one of the most important and critical quality parameters in aquaculture farms. The main objective of this study was to evaluate the potential of two Continuous Flow Granular Reactors, one based on Partial Nitrification-Anammox biomass (Aquammox CFGR) and the other on Microalgae-Bacteria biomass (AquaMab CFGR), for improving dissolved oxygen availability in the recirculation aquaculture systems (RAS). Both reactors treated the extremely low-strength effluents from a freshwater trout farm (1.39 mg NH4 +-N/L and 7.7 mg TOC/L). The Aquammox CFGR, removed up to 68% and 100% of ammonium and nitrite, respectively, but the DO concentration in the effluent was below 1 mg O2/L while the anammox activity was not maintained. In the AquaMab CFGR, bioaugmentation of aerobic granules with microalgae was attained, producing an effluent with DO concentrations up to 9 mg O2/L and removed up to 77% and 80% of ammonium and nitrite, respectively, which is expected to reduce the aeration costs in fish farms.info:eu-repo/semantics/publishedVersio

Respiratory Syncytial Virus Coinfections With Rhinovirus and Human Bocavirus in Hospitalized Children

It is not clearly established if coinfections are more severe than single viral respiratory infections.The aim of the study was to study and to compare simple infections and viral coinfections of respiratory syncytial virus (RSV) in hospitalized children.From September 2005 to August 2013, a prospective study was conducted on children younger than 14 years of age, admitted with respiratory infection to the Pediatric Department of the Severo Ochoa Hospital, in Spain. Specimens of nasopharyngeal aspirate were taken for virological study by using polymerase chain reaction, and clinical data were recorded. Simple RSV infections were selected and compared with double infections of RSV with rhinovirus (RV) or with human bocavirus (HBoV).In this study, 2993 episodes corresponding to 2525 children were analyzed. At least 1 virus was detected in 77% (2312) of the episodes. Single infections (599 RSV, 513 RV, and 81 HBoV) were compared with 120 RSV-RV and 60 RSV-HBoV double infections. The RSV-RV coinfections had fever (63% vs 43%; P < 0.001) and hypoxia (70% vs 43%; P < 0.001) more often than RV infections. Hypoxia was similar between single or dual infections (71%). Bronchiolitis was more frequent in the RSV simple group (P < 0.001). Pediatric intensive care unit admission was more common in RSV simple or RSV-RV groups than in the RV monoinfection (P = 0.042).Hospitalization was longer for both RSV simple group and RSV-HBoV coinfection, lasting about 1 day (4.7 vs 3.8 days; P < 0.001) longer than in simple HBoV infections. There were no differences in PICU admission. RSV single group was of a younger age than the other groups.Coinfections between RSV-RV and RSV-HBoV are frequent. Overall viral coinfections do not present greater severity, but have mixed clinical features.This study has been partially supported by FIS (Fondo de Investigaciones Sanitarias – Spanish Health Research Fund) Grants No.: PI06/0532, PI09/00246, and PI12/01291.S